The game tells the story of Huang Lee, a Chinese immigrant that's looking for revenge in the American city of Liberty City. To do this, as is usual on GTA, he'll have to establish all kinds of deals with all kinds of criminals, as well as steal cars, kill people, etc.
This latest installment represents a return to its origins, in so far as playability, as the perspective goes from the classic third person GTA3 view you've probably become accustomed to, to the birds-eye view of the first two games.
Grand Theft Auto: Chinatown Wars is an amazing game in every possible way, lasting over 20 hours. A must-have for fans of the saga.